Also, the fact that India had won all three previous contests against South Africa at the Wankhede Stadium should also give the home team a boost.
While both teams have been undone by injuries to key players, India have been able to fill the void left by the unavailability of top off-spinner Ravichandran Ashwin after the opening Kanpur game more effectively with veteran Harbhajan Singh performing admirably.
South Africa had lost the services of their key all-rounder Jean-Paul Duminy for the last two games due to a hand injury sustained in the third match of the series in Rajkot.
Fast bowler Morne Morkel too sustained a leg injury in Rajkot and missed the Chennai game and his absence also hurt the visitors badly.
The return to top form of Virat Kohli, who struck a fine half century (77) in vain in the third match and then made a brilliant 140-ball 138 at Chennai, will be of great boost for the hosts.